DESCRIPTION:

Thapsigargin is the most widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca2+-ATPases in mammalian cells. A guaianolide compound of plant origin, it has become a commonly used research tool in the elucidation of the mechanisms of intracellular Ca2+ signalling.

Its remarkable potency and selectivity have been instrumental in developing our understanding of the function of intracellular Ca2+ stores, including store-operated Ca2+ entry or the involvement of the stores in protein synthesis or cell growth.

DATA SHEET:

Chemical name (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
CAS number 67526-95-8
Molecular weight 650.8
Formula

C34H50O12
Solubility Soluble in DMSO up to 100 mM
Purity >98%
Storage -20°C
Datasheet A010-503
Regulatory statement Product for research use only. Not intended for diagnostic or therapeutic use.