DESCRIPTION:
GFCPDHKAAMVLFLDSVYGIEVQDFLLHLLEVGFLP
DPc10inactivepeptideisa36-residuepeptidethatdiffersfromDPc10(Gly2460-Pro2495,rabbit)atoneposition(R2475S)andrepresentsthesequenceofaknownCPVTmutantRyR2domain.ThispeptidebindsweaklyorfailstobindtotheDPc10interfaceanddoesNOTaffectchannelfunction.ItservesasanegativecontrolforresearchprojectsusingDPc10peptide.
DPc10inactiveinthecurrentformisnotcellpermeable.TheproductisusefulinapplicationsthatpermitaccesstoRyR2directly(viawholecellpatch,skinnedcells,blacklipidmembrane,vesicles,orupondeliverytocytoplasm).
ReadDPc10Publications 
DATASHEET:
| Peptidename | DPc10InactivePeptide |
| Peptidesequence | GFCPDHKAAMVLFLDSVYGIEVQDFLLHLLEVGFLP |
| N-terminus | Amine |
| C-terminus | Acid |
| Counterions | Trifluroacetate(TFA) |
| Molecularweight | 4034.726 |
| HPLCanalysis | Analysiscarriedoutusinga100A4.6x150mmcolumn,grADIentfrom10%-90%acetonitrile,in15minutes.60degC.Puritydeterminedas95%. |
| MSanalysis | Molecularionpredicted:4034.726.Observed:4034.1[M+3H] |
| Appearance | Offwhitepowderedsolid |
| Solubilisation | DMSO |
| Storage | Storeassuppliedat-20°Cforupto1year.Storedesiccated.Makefreshsolutionspriortouse. |
| Datasheet | A010-515ReadDPc10Publications |
| MSDS | A010-515 |
| Notes | Theproductwaspurifiedinacetonitrileandwatercontaining0.1%trifluoroaceticacid(TFA)priortolyophilisation.Theproductwillthereforebepresentasitstrifluoroaceticacidsalt. *Peptideissuppliedbynetpeptideweight. Whilstthepurityofthematerialhasbeenshowntobe>95%,thenetpeptidecontentislowerduetocounterionsandresidualwaterpresentinthematerial. Tocompensateforthistheamountofpeptideweighedoutisadjustedsothattheamountofactivematerialreceivedisexactlyasstatedonthevial. Thismeansthatthetotalmasswillbeinexcessof200µg,buttherewillbeexactly200µgoftheactivepeptideinthevial.Theremainderoftheweightisduetothecounterionsandresidualwater. |
| Regulatorystatement | Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse. |
